Modeling the Actions of β-Adrenergic Signaling on Excitation-Contraction Coupling Processes
نویسندگان
چکیده
منابع مشابه
Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.
RATIONALE Rad (Ras associated with diabetes) GTPase, a monomeric small G protein, binds to Ca(v)beta subunit of the L-type Ca(2+) channel (LCC) and thereby regulates LCC trafficking and activity. Emerging evidence suggests that Rad is an important player in cardiac arrhythmogenesis and hypertrophic remodeling. However, whether and how Rad involves in the regulation of excitation-contraction (EC...
متن کاملRad As a Novel Regulator of Excitation–Contraction Coupling and -Adrenergic Signaling in Heart
sarcoplasmic reticulum release. Conversely, 70% Rad knockdown by RNA interference increased ICa (50%), [Ca ]i transients (52%) and contractility (58%) without altering EC coupling efficiency; and the dominant negative mutant RadS105N exerted a similar effect on ICa. Rad upregulation caused depolarizing shift of LCC activation and hastened time-dependent LCC inactivation; Rad downregulation, how...
متن کاملAltered Excitation-Contraction Coupling
Heart Failure After Myocardial Infarction : Altered Excitation-Contraction Coupling Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/hc3201.092285 2001;104:688-693 Circulation. http://circ.ahajournals.org/content/10...
متن کاملExcitation-Contraction Coupling
Previous studies have demonstrated that the ability of (.adrenergic receptor (.BAR) stimulation to increase cardiac contractility declines with aging. In the present study, the control mechanisms of excitation-contraction (EC) coupling, including calcium current (Ice), cytosolic Ca2" (Ca?') transient and contraction in response to BAR stimulation were investigated in ventricular myocytes isolat...
متن کاملDecreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways.
Cardiac disorders are the main cause of mortality in autosomal-dominant polycystic kidney disease (ADPKD). However, how mutated polycystins predispose patients with ADPKD to cardiac pathologies before development of renal dysfunction is unknown. We investigate the effect of decreased levels of polycystin 2 (PC2), a calcium channel that interacts with the ryanodine receptor, on myocardial functi...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2004
ISSN: 0077-8923,1749-6632
DOI: 10.1196/annals.1302.002